COVID-19 Science

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"One of the possible explanations is the replication conflict among respiratory viruses. Co-infection of winter respiratory viruses and spring respiratory viruses in the animal model may provide insights into the unknown mechanisms of spring-to-summer epidemics. Another unresolved issue is the observation that even in the highly controlled environment of the animal housing setting (22.2°C, 50% RH, controlled light/dark cycle) using the same viral stock, rate of transmission of influenza virus was higher when the experiments were carried out in the winter (November to April, 58.2%) versus summer (May to October, 34.1%) (65). Thus, in addition to temperature, lighting, and humidity, there may be other environmental factors controlled by the seasons that contribute to higher levels of influenza virus infections in the winter months."